http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-190710-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f2bd3d611c7a2a832128d8430d9193 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-36 |
| filingDate | 1997-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6a7bcc79ed1ae0e0bae8ea4e0502231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f08385337563230fd7bd0a184131e958 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5435360ecefc7b321760ea2fe07275b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24e81d936175c3b72fea7dadbfba8366 |
| publicationDate | 2005-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-190710-B1 |
| titleOfInvention | Adamantylroretinoid Compounds, their uses as anti-cancer agents, and compositions containing these compounds |
| abstract | 1. Use of an adamantylretinoid compound in the manufacture of a medicament for use in a methodncancer treatment by inducing cancer cell apoptosis, or for usenin a method of preventing cancer or precancerous conditions, wherein the adamantyloretinoid isna compound of one of the following general formulas, or a pharmaceutically acceptable thereofnsalt or optical and / or geometric isomer:ncompound of general formula (I)n(Ϊ)nwith the proviso that the retinoid of formula (I) is not a ligand for a receptor specific agonistnRAR-γ having a dissociation constant for the RAR-α type receptor at least 10 timesngreater than the dissociation constant for the RAR-γ-type receptor and which induces cell differentiationnF9 in whichnW is independently -CH2-, -O-, -S-, -SO- or -SO2-,nX is a substituent selected from the groups of the following formulas (i) - (iii): where Y is -CO-V-, -CH = CH-, -CH3C = CH-, -CH = CCH3-,nNHnCH11 2 -c- -CHOH -CH2-O orn2nN "nV is oxygen (-O-), aza (-NH-), CH = CH- or -C = C-;nZ is the group -CH- and Z 'is oxygen, ornZ is nitrogen (N) and Z 'is aza (-NH-):nR1 is hydrogen, halogen or lower alkyl,nR'i is hydrogen, halogen or lower alkyl;nR2 is hydroxy, alkyl optionally substituted with one or more hydroxyl groupsnor acyl, alkoxy optionally substituted with one or more hydroxyl groups,nalkoxy or aminocarbonyl, and / or optionally interrupted by onenor more oxygen atoms, acyl, aminocarbonyl or halogen;nR3 is hydrogen, hydroxy, alkyl or alkoxy;nR2 and R3 together may form a -O-CH2-O- group;nR4 is hydrogen, alkyl, alkoxy or halogen; |
| priorityDate | 1996-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 307.