| abstract |
The invention concerns novel counterparts of camptothecin and particularly the products complying with the following formulae: -5-ethyl-9,10-difluoro-4,5-dihydro-5-hydroxy-12- (4-methyl piperidinomethyl) -1H-oxepino[3', 4':6,7]indolizino[1,2-b] quinolein-3,15(4H,13H)-dione; -5-ethyl-12-diethylaminomethyl-9-fluoro-4,5-dihydro-5-hydroxy-10-methyl-1H-oxepino [3',4':6,7] indolizino[1,2-b]quinolein-3,15(4H,13H)-dione; -5-ethyl-9-fluoro-4,5-dihydro-5-hydroxy-10-methyl-12- (4-methyl piperidinomethyl) -1H-oxepino[3',4':6,7]indolizino[1,2-b]quinolein-3,15(4H,13H)-dione. The invention also concerns their application as medicines, the pharmaceutical compositions containing them and their use in producing tumoricidal, antiviral or parasiticide medicines. |