http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-184291-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 |
| filingDate | 1996-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dcceea2c784d7427f69a3627fbd8167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66afe087559c6026510ba21f044e15d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8e336df82a2eb79feebe456ad7deb1a |
| publicationDate | 2002-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-184291-B1 |
| titleOfInvention | Method for producing cyclosporin |
| abstract | 1. A method for the preparation of cyclosporine of formula IIn-A-B-X-MeLeu-Y-Mel_eu-Ala- (D) Ala-MeLLu-MeL.LU-MeVal i- 1234567 8 9 10 11nwhereinnA is a 3'-deoxy-3'-oxo-MeBmt residue;nB is -aAbu-, -Thr-, -Val-, or -Nva-;nX is -Sar- or an optically active residue, an α-N-methylated α-amino acid residue,nhaving (D1-configuration andnY is Val or additionally when B jdst Nva, Nvv,ninvolving the cultivation of a suitable organism to produce cyclosporin intermediatenand recovering the intermediate cyclosporin from the culture medium, characterized by the intermediatencyclosporin of formula II where A is MeBmt is selectively oxidizednat a temperature of -15 ° C to + 20 ° C, using dimethylsulfoxide as the oxidizing agentnin combination with N, N'-dicyBlohexylBorbodiimide or dodecylmethylsulfoxide in combinationnwith N, N'-dicyBloheBsylBarbodiimide. |
| priorityDate | 1996-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.