http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-182916-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80f9f6e939f5a2e10c0e9478c70b4b0e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-02 |
| filingDate | 1996-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6765e3d0028150b75dee6037d0e67abc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19486a4dfc319a6f2b6f070963e027a5 |
| publicationDate | 2002-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-182916-B1 |
| titleOfInvention | The method of obtaining new ethyl esters of Ssinaa 1 -aryl-5 (1H) hydroxy-2,3-dihydroimidazo [2,1-c] [1,2,4] triazepine-6-carboxylic acids |
| abstract | Method for obtaining new ethyl estersn57) 1-aryl-5 (1H) hydroxy-2,3-dihydroimidan'7o [2,1-c] [1,2,4] triazepine-6-carboxylic acids of the formulangeneral 1 in which it represents hydrogen, halogen, CMalkyl,ncharacterized in that ethoxymethylene malonatendiethyl (DEEM) of general formula 2 is reactednpseudo-Michael with 1-aryl-2-hydrazinoimidazolinatenFormula 3, wherein R is hydrogen, halogen,na C1-4 alkyl group which can be obtained by neutralizationnaqueous solutions of hydroiodine solutionsnalkali, preferably sodium, potassium hydroxidenand extraction with haloalkanes or hydrocarbonsnaromatics, preferably methylene chloride, chloroform,ntoluene, benzene, with a pseudo-Michael reactionncarried out in a temperature range from temperaturenroom temperature to the boiling point of low-boiling alcohol,npreferably ethyl, methyl, isopropyl alcoholnfor 6-24 hours at a molar ratio of 1Ί,nthe resulting diethyl chain esters are then cyclizedn2- (1-arylimidazolin-2-yl) hydrazinomethylene malonic acidsnof general formula 4, wherein R isnhydrogen, halogen, C1- alkyl by heatingnat the boiling point of aromatic hydrocarbons,npreferably xylene, toluene, benzene, decalin, etc.n2-6 hours and the product is an isomeric mixturen1-aryl-5 (1H, 8H) oxo-2,3-dihydroimidazo [2,1-c] [n1,2,4] triazepine-6-carboxylic acidnof general formula 5 in which R is hydrogen,nhalogen, C14aIkyl group and esters |
| priorityDate | 1996-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.