http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-175927-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-20 |
| filingDate | 1994-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a91cef0dfc2d0e7b4c99b82b429792d0 |
| publicationDate | 1999-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-175927-B1 |
| titleOfInvention | New sulfonamides |
| abstract | Compounds of the formula <CHEM> wherein: R is phenyl, naphthyl or biphenyl, each of which may be substituted with R<1>, R<2> and R<3>; R<4>,R<5> and R<1><2> are each independently <a) hydrogen; <b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z<1>, Z<2> and Z<3>; <c) halo; <d) hydroxyl; <e) cyano; <f) nitro; <g) -C(O)H or -C(O)R<6>; <h) -CO2H or -CO2R<6>; <i) -SH, -S(O)nR<6>, -S(O)m-OH, -S(O)m-OR<6>, -O-S(O)m-R<6>, -O-S(O)mOH or -O-S(O)m-OR<6>; <j) -Z<4>-NR<7>R<8>; <k) -Z<4>-N(R<1><1>)-Z<5>-NR<9>R<1><0>; or <l) R<4> and R<5> or R<5> and R<1><2> together are alkylene or alkenylene (either of which may be substituted with Z<1>, Z<2> and Z<3>), completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached; provided that when R is phenyl, at least two of R<4>, R<5> and R<1><2> are other than hydrogen; R<1>, R<2>, R<3>, R<6>, R<7>, R<8>, R<9>, R<1><0>, R<1><1>, Z<1>, Z<2>, Z<3>, Z<4>, Z<5>, n and m are as defined in the description; and pharmaceutically acceptable salts thereof are endothelin receptor antagonists useful, inter alia, as antihypertensive agents. |
| priorityDate | 1993-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 279.