http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-172229-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-16 |
| filingDate | 1993-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4dc5e1e7b22f6fdf7dcada1411a226a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a30918c390ed1673f3eb256e882d81aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f366353fed602cdbc3b3c7f4350d14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a32bf72a0d8875c2e32dd7be9946abd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2b51d4b18da0aefaf26c84aa80acd47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5690141bd0d07bcaaefe2569c6017db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4810fa3a486efbdd61c1c5fee2361261 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0886412cf27042224d768420629ebc13 |
| publicationDate | 1997-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-172229-B1 |
| titleOfInvention | Internal phosphinyloxypropane amine salt derivatives PL |
| abstract | 1 Pharmacologically active derivatives of phosphinyloxypropanamim inner salts of the formula I, wherein X 1 1 X 2 are independently of one another being oxygen or sulfur; R1 represents the group R5 -Y- R6 - or R7-Z-R8-, wherein Y is -O-, -S-, -CH2-, -CH = CH-, -C = C-, -N (R1 0 ) CO- or-CON (R10) -, Z is -O -S- or -CH2-; R5 is straight or branched (C1-17) alkyl, or straight or branched α-trifluoro- (C1-8) alkyl; R6 is (C2-18) alkylene chain straightened; and the total number of carbon atoms in R5-Y-R6 - is 7 to 19; R7 is unsubstituted phenyl, phenoxyphenyl, biphenyl, naphthyl or naphthoxyphenyl; or phenyl, phenoxyphenyl, biphenyl, naphthyl or naphthoxyphenyl mono- or independently di- or independently t disubstituted by halogen, NO2, NH2, CN, (C1-8) alkyl, (C1-8) alkoxy, trifluoromethyl, triluoromethoxy or acetyl group wa; R8 is straight-chained (C3-15) alkylene, groups- (CH 2) 10N (R10CO- (CH2) n, - (CH2) m -CON (R1 0) - (CH2) n - or -CH2R11OR12- where min independently of each other are equal to 1 to 7; R10 is hydrogen, methyl or ethyl; R u is straight or branched (C1-7) alkylene; R12 is straight chain (C2-7) alkylene and the total number of carbon atoms in aryl in R7 and the total number of carbon atoms in R8, not counting R1 0, ranges from 3 to 15; and R2, R3 and R4 each, independently of each other, represent straight-chain or branched (C1-4) alkyl, in the form of the free acid or salt, physiologically hydrolysable ester or prodrug selected from the group consisting of pivaloyloxymethyl esters, 4- (2-methoxyphenoxy) -2-methylbutyryloxymethyl, N, N-dimethoxyethylcarbamoylmethyl, N- (3,6,9-trioxadecyl) - N-methylcarbamoylmethyl, N- (3,6-dioxaheptyl) -N-methylcarbamoylmethyl, N, N-dipentylcarbamoylmethyl, N, N-dipropylcarbamoylmethyl y, N, N-dibutylcarb moylmethyl and N- (2-methoxyphenoxyethyl) -N-methylcarbamoylmethyl carnitine MODEL 1 E L 172229 B 1 EN |
| priorityDate | 1993-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.