| abstract |
1. The method of producing new amidesnFormula I wherein E is nitrogen orn"CZ group where C is a ring carbonnand Z is a defined substituentnbelow, in which when E is CZ, Xnrepresents the group ArY, where Y is a groupnlinking such as sulfinyl and sulfonyl and Arnis phenyl, Z is cyano,nwhen E is nitrogen, X and Y are as defined aboventhe meaning, R2 and R 'are independently methylnor trifluoromethyl, provided that r2nand R 'simultaneously cannot be methylnand their pharmaceutically acceptable salts,ncharacterized in that the responder is oxidizednthe phenylsulfide of the compound of Formula 1, wnwherein Y is sulfur and the other substituentsnhave the meaning given above, afternwhich, when desired, is pharmaceutically acceptablensalt, the resulting amide is subjectednis reacted with an appropriate acid or basenknown way. |