http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-167139-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6964dd554699a48f7b052fd2acf89e3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 |
| filingDate | 1991-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b225aea822e5eeb1b4561bdd387e204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12e2da0e97639461033b310c41980d4a |
| publicationDate | 1995-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-167139-B1 |
| titleOfInvention | Method for the production of Na-benzyloxycarbonyl-D-O-t-butylseryl-Lleucyl-L-arglnyl-L-proline N-ethylamide acetate |
| abstract | Method for the production of Na-benzyloxycarbonyl-D-O-t-butylseryl-L-leucyl-L-arginyl-L-proline N-ethylamide acetate,ncharacterized in that Na-benzyloxycarbonyl-L-proline N-ethylamidenis treated in the presence of 1-hydroxybenzotriazolenof hydrogen in the presence of a catalyst, the obtained L-proline N-ethylamide condenses with benzotriazolylanenNα-benzyloxycarbonyl-L-arginine using dicyclohexylcarbodiimide to givenNa-benzyloxycarbonyl-L-arginyl-L-proline N-ethylamide benzotriazolylate, whichntreated with hydrogen against 1-hydroxybenzotriazole and then combined with Na-benzyloxycarbonyl-L-leucinenwith dicyclohexylcarbodiimide and the resulting tripeptide,nNa-benzyloxycarbonyl-L-leucyl-L-arginyl-L-proline N-ethylamide benzotriazolylate,nis subjected to a hydrogenolysis reaction in the presence of a catalyst and then added to Nabenzyloxycarbonyl-D-O-t-butylserinenwith dicyclohexylcarbodiimide and 1-nhydroxybenzotriazole to give the tetrapeptide, N-ethylamide benzotriazolylatenNa-benzyloxycarbonyl-D-O-t-butylseryl-L-leucyl-L-arginyl-L-proline which purifiesnby silica gel column chromatography on the systemnacetic acid-containing solvents to yield Na-benzyloxycarbonyl-D-O-t-butylseryl-L-leucyl-L-arginyl-L-proline N-ethylamide acetate. |
| priorityDate | 1991-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.