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filingDate 1990-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1995-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PL-166659-B1
titleOfInvention A method of producing a gamma globulin fraction capable of passive protection against PL meningitis
abstract Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.
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