http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-162389-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-30 |
| filingDate | 1988-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-162389-B1 |
| titleOfInvention | Method for the preparation of new 2-substituted 6-cycloalkylpyrimidines |
| abstract | The method of making new 2-substituted 6-ncycloalkylpyrimidines of the formula where Ro isnhalogen, R3 represents a hydrogen atom, a C1-6alkyl radicalnoptionally substituted with halogen,nhydroxyl or cyano, cyclopropyl radicalnpossibly up to three times, equallynor variously substituted with methyl and / or halogen,nR4 is a C3-C6-cycloalkyl radical optionallynat most three times, equally or differently substitutednwith a methyl group and / or a halogen group and R5nrepresents a C1 -Ca-alkyl radical or optionally a halogennor a C1-C4-alkyl group substituted radicalnbenzylic acid, characterized in that the urea of formula IVznThe ditone of formula III is reacted innthe presence of an acid in an inert solventnat a temperature of 20-140 ° C, preferably at a temperaturen20-40 ° C, and cyclizes to the pyrimidine compound onin formula 5, the OH group of the resulting compound is mentionednto a halogen atom with an excess of the compoundnPOHab with or without a solvent at temperaturen50-10 ° C, preferably at reflux temperaturenPOHals against condensate return. |
| priorityDate | 1988-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.