http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-161576-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1988-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-161576-B1 |
| titleOfInvention | Method for the preparation of new 2-anilinopyrimidine derivatives |
| abstract | Method for the production of new 2-anilino derivativesnpyrimidines of general formula I, wherein Ri and R2 independentlynthey represent a hydrogen atom, a halogen atom,nC1 -C3-alkyl radical, C1 -C2-haloalkyl radical,na C1-C3 alkoxy group or a C1-C3 haloalkoxy group,nR3 represents a hydrogen atom, the radical C1-C4-nalkyl optionally substituted with halogen, a groupnhydroxyl or cyano, cyclopropyl radicalnpossibly up to three times, equally or differentlynsubstituted with methyl and / or halogen, and R4nis a C3-C6-cycloalkyl radical and optionally conup to three times, equally or differently substitutednwith a methyl group and / or a halogen, characterized in thatnurea of formula 2 with dichotone of formula 3 is introducednreact in the presence of an acid in an inert mediumnsolvent at a temperature of 20-140 ° C andnthen at refluxncyclizes to the pyrimidine compound of formula 4, wnof the obtained compound, the OH group is replaced by an atomnhalogen with an excess of a compound of formulanPOHaU with or without solvent at temperaturen50-110 ° C to give the compound of formula 5, whilenwhere in the previous formulas the symbol Hal represents an atomnhalogen, and the resulting compound of formula 5 is processednfurther reaction at a temperature of 60-120 ° C. |
| priorityDate | 1988-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.