| abstract |
A process for the preparation of the aryl-piperazinyl-alkylene phenyl-p-heterocyclic compounds of formula 1 and their pharmaceutically acceptable addition salts, in which formula 1, Ar is a phenyl group or a 3-trifluoromethyl phenyl group, a 3-cyanopyridine group, 1-naphthyl, 1- (6-fluoronaphthyl), 1- (6-chloronaphthyl), 3-benzisothiazolyl or 8-quinolyl, n is 2,3 or 4, R is a hydrogen atom or a group (C1 -C 3) alkyl and ZY is CH, C-OH, CN H 2, C- (C 1 -C 3) alkyl C- (C 1 -C 3) alkyl amine or nitrogen, characterized in that the piperazine of formula 3 is The reaction with the compound of formula IV, in which Hal is fluoro, chloro, bromo or iodo, and R, R and ZY in formulas 3 and 4 have the meaning given above. Ar-N NHCH2) n R N Z-Y Formula 1 PL PL PL PL |