http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-154625-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 1989-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1991-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-154625-B1 |
| titleOfInvention | Method of obtaining l-alanyl-l-proline |
| abstract | Prodn. of L-alanyl-L-proline derivs. of formula (I), where R is ethyl or hydrogen, or their pharmaceutically acceptable salts, involves reacting derivs. of proline and N(1(S)-ethoxycarbonyl- 3-phenylpropyl)- L-alanine in solvent at (-5) to (20) deg.C. The proline deriv. comprises N-O-bis-trimethylsilyl- L-proline of formula (II). The deriv. of N(1(S)-ethoxycarbonyl- 3-phenyl-propyl)- L-alamine has formula (III), where Het is imidazolyl-1 or benzothiazolyl-2-thio. The condensn. reaction is carried out in non-polar organic solvent, esp. in dioxane, tetrahydrofuran or methylene chloride. When required, the obtd. cpd. of formula (I) in which R is ethyl is hydrolysed to obtain a cpd. of formula (I) in which R is hydrogen. Yield is 76%; m.pt. is 146-152 deg.C. When the maleate is required, a cpd. of formula (I) in which R is ethyl is treated with maleic acid. Yield is 83% and m.pt. is 143-147 deg.C. |
| priorityDate | 1988-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.