http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-153727-B1
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-26 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 |
filingDate | 1987-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1991-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PL-153727-B1 |
titleOfInvention | A method of 1,2,3,4-tetrahydropirymidinecarboxyl-5 acid derivatives production |
abstract | Cardiovascular activity is exhibited by compounds having the formula <CHEM> and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R1 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, <CHEM> or halo substituted alkyl, or R and R1 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, <CHEM> or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, <CHEM> or halo substituted alkyl; R4 is aryl or heterocyclo; R5 and R6 are each independently hydrogen, alkyl, -(CH2)q-aryl or -(CH2)q-cycloalkyl; Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, (substituted amino)- @-, heterocyclo-(CH2)m- @-, carboxyl, alkoxycarbonyl, alkyl- @-, aryl-(CH2)m- @-, alkyl-@-O- or aryl-(CH2)m- @-O- Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, (substituted amino)- @-, carboxyl, alkoxycarbonyl, alkyl- @-, aryl-(CH2)m- @- or heterocyclo-(CH2)m- @-; Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, alkyl- @-O-, aryl-(CH2)m- @-O-, amino, or substituted amino; q is 0, 1, 2 or 3; m is 0 or an integer of 1 to 6; n is 0 or an integer of 1 to 5; and p is an integer of 1 to 5. 5 |
priorityDate | 1986-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.