http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PH-12015501498-A1

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publicationDate 2015-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PH-12015501498-A1
titleOfInvention 8 - carbamoyl - 2 - (2,3- di substituted pyrid - 6 - yl) -1,2,3,4 -tetrahydroisoquinoline derivatives as apoptosis - inducing agents for the treatment of cancer and immune and autoimmune diseases
abstract Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
priorityDate 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 45.