abstract |
THEY REFER TO COMPOUNDS OF FORMULA (3), WHERE: R1 IS VINYL OR ETHYL; R2 IS R3, -CH2R4, -CH = CR5R6; R3 AND R4 ARE AN AZABICLIC RING or R5 AND R6 TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE UNITED FORM A AZABICICLIC RING, WHERE SUCH A AZABICICLIC RING IS SELECTED FROM: AZABICICLO [2.2.2] OCTILE, AZABICICLO [2.2.1] AZABICICLO [3.2.1] OCTILE, AZABICICLO [4.4.0] DECILO, QUINUCLIDINYL, AZABICICLO [3.2.1] OCTENYL AND AZABICICLO [3.3.1] NON-5-ILO. IT ALSO REFERS TO THE PREPARATION PROCEDURE OF (3), WHICH INCLUDES: (a) REACTION A COMPOUND OF FORMULA (4), WHERE "X" IS H OR A HYDROXYL PROTECTIVE GROUP, OR A COMPOUND OF FORMULA (5) : R3CONCO, R4CH2CONCO or R5R6C = CHCONCO; or (b) REACT A COMPOUND (4) or A COMPOUND (5) WITH R3COCl, R4CH2COCl or R6R5C = CHCOCl, IN THE PRESENCE OF SILVER CYANATE AND A BASE, WHERE: R3, R4, R5 AND R6 IS PROTECTED WHEREVER NECESSARY. THE COMPOUNDS OBTAINED PRESENT IMPROVED ANTIMICROBIAL PROPERTIES, BEING USEFUL IN THE MEDICAL AND VETERINARY TREATMENT OF INFECTIONS CAUSED BY POSITIVE GRAM BACTERIA, NEGATIVE GRAM AND MICOPLASMAS |