| abstract |
IT REFERS TO A COMPOUND OF FORMULA (I), WHERE R1 IS H, OH, C1-C8 ALKYL, C1-C8 ALCOXY, AMONG OTHERS; R2 IS H; R3, R4, and R5 ARE H, OH, HALO, TRIFLUOROMETHYL, C1-C8-ALKYL, C1-C8-ALCOXY, (O or NH) m- (CH2) n-R9, AMONG OTHERS; R9 IS H, OH, COOH, NR10R11, n IS 0-4; m ES 0 � 1; R10 AND R11 ARE H or C1-C8 ALKYL or TOGETHER WITH NITROGEN FORM A RING OF 3 TO 10 MEMBERS WITH 1-3 O, S or NH; R6 IS H, C1-C8-ALKYL, ARYL, ARALKYL OR C3-C10 CYCLOALKYL; R7 IS H, C1-C8 ALKYL, C2-C8 ALKYLLL, C2-C8 ALKYLLL, BETWEEN OTHERS OR R6 AND R7 TOGETHER WITH N-O FORM A RING OF 5 TO 10 MEMBERS OPTIONALLY REPLACED WITH 1-3 O, S or NR10R11. A PREFERRED COMPOUND IS 4-FLUORINE-N-HYDROXY-2- (4-IODINE-2-METHYL-PHENYLAMINE) -BENZAMIDE, AMONG OTHERS. COMPOUND I INHIBITS THE ENZYMES OF CINASA MEK, MAY BE USEFUL TO TREAT PROLIFERATIVE DISEASES SUCH AS PSORIASIS, RESTENOSIS, CANCER, AUTOIMMUNOLOGICAL DISEASE, APHERYCLAP, HARDNESS, HEART DISEASE |