| abstract |
THEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: R IS LOWER RENT, PHENYL, BENCIL, PIRIDYL OR TENYL, WHICH ARE OPTIONALLY SUBSTITUTED BY ONE OR MORE RENT LOWER, BEFORE, OR OTHER ; R1, R2, R3 AND R4 ARE H, NO2, HALOGEN, LOWER ALCOXYL, or CF3, AMONG OTHERS, OR R1 AND R2, or R2 AND R3 MAY FORM AN OPENALLY SUBSTITUTED BENZENE RING, CF3, NO2, LOWER ALKYL, or ALCO. THEY ALSO REFER TO THE PREPARATION PROCEDURES OF THE FORMULA COMPOUNDS (I). THE COMPOUNDS OBTAINED ACT AS INHIBITORS OF THE ENZYME QUINURENIN-3-HYDROXYLASE IN THE DEGRADATION ROUTE OF TRYPTOPHANE, REDUCING THE FORMATION OF THE QUINOLINIC ACID (NEUROTOXICO), PORINOURIC ACID, and TREATMENT OF NEURODEGENERATIVE DISORDERS LIKE AMIOTROPHIC LATERAL SCLEROSIS OR EPILEPSY, OF NEUROLOGIC DISORDERS RESULTING FROM AN ACTIVATION OF THE IMMUNE SYSTEM, AS VIRAL OR BACTERIAL MENINGITIS, OCHSIAR ESTROSIS, AND ESCHOESIS |