| abstract |
THEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: "X" IS N or CH; "Y" IS WCH2, CH2W or W, WHERE "W" IS O, S (O) m or NRa, WHERE m IS 0; 1 or 2; Ra ES H or C1-C8 ALKYL; R "IS OF PREFERENCE FURANO, IMIDAZOL, TRIAZOL, PIRROLIDINA, PIPERAZINA, PIPERIDINA, R" OPTIONALLY REPLACED BY R1; n IS 0 or 1; R1 IS AMINE, H, HALOGEN, CARBOXY, 1,3-DIOXOLAN-2-ILO OR METILSULFONILETILAMINO, AMONG OTHERS; p IS 0; 1; 2 or 3; OR WHEN p IS 2 or 3, TWO ADJACENT R1 GROUPS TOGETHER TOGETHER A METHYLENDIOXI OR ETHYLENDIOXI GROUP; R2 IS H, HALOGEN, CF3, C1-C4 ALKYL OR C1-C4 ALCOXY; "A" IS A HETERO CYCLIC RING, OF PIRIDINE PREFERENCE; "U" IS A MONO- OR BI-HETERO-CYCLE SYSTEM OF 5 TO 10 MEMBERS, PREFERABLY IS INDAZOLYLL OR INDOLYLL, "U" MAY BE REPLACED BY R6 AND R4, WHERE R4 IS HYDROXY OR HALOGEN, AMONG OTHERS; R6 IS PREFERRED BENZYL, FLUOROBENCIL, PYRIDYLMETHYL OR BENZENE SULFONYL. IT ALSO REFERS TO THE PROCEDURE FOR PREPARING THE COMPOUNDS (I) AND THE INTERMEDIATE COMPOUNDS FOR THEIR OBTAINING. THE COMPOUNDS OF FORMULA (I) ACT AS SELECTIVE INHIBITORS OF PROTEIN THYROSINE KINASES, BEING PREFERRED EGFr, c-erB-2, c-erB-4, SUCH SELECTIVITY MINIMIZES POTENTIAL SIDE EFFECTS IN UTILES BY INHIBITING UNCONTROLLED CELL PROLIFERATION |