| abstract |
IT REFERS TO A COMPOUND OF FORMULA (I) OR ITS SALTS, WHERE m, n, p, AND t ARE O-1; o Y r ARE 0-4; q IS 0-3; A ES O,> NH or S; B ES O or NH; D ES O or NR9; R9 IS H, C1-C6-ALKYL; "E" IS CH2, O, NH or S (O) a, to ES 0-2; R1 IS H, ALKYL C1-C6, HETEROCICLO C3-C7, AMONG OTHERS, OPTIONALLY CONTAINING 1-4 O, S, N, NR9, AND OPTIONALLY SUBSTITUTED WITH 1-3 HALO, CN, CARBOXI, AMONG OTHERS; R2, R3, and R4 ARE H, OH, HALO, C1-C6 ALKYLAMINE, AMONG OTHERS; OR R2 AND R3 TOGETHER TOGETHER A CARBONYL OR FORM A CYCLOALKYL C3-C7, AMONG OTHERS; R5 IS C3-C7 HETERO CYCLE, CYCLIC OR BICYCLE, SATURATED OR UNSATURATED CONTAINS 1-4 O, S, N, NR9, OPTIONALLY SUBSTITUTED, AMONG OTHERS; R11, R12, R13, R14 AND R15 ARE H, HALO, CN, NCOR10, AMONG OTHERS; R6, R7 AND R8 ARE H, HALO, CN, CARBOXI, AMONG OTHERS; OR R7 AND R8 TOGETHER TOGETHER A CONDENSED BICYCLE RING OF FORMULA II; M, P, Q, T SON O, N, CR17; R17 IS H or C1-C6 ALKYL. A PREFERRED COMPOUND IS N- (4- (1-HYDROXY-1-METHYL-ETHYL) -BENCIL) -2- (3-METHYL-BENZO (d) -ISOXASOL-7-ILOXI) -NICOTINAMIDE; AMONG OTHERS. THE COMPOUND OF FORMULA (I) IS A SELECTIVE INHIBITOR OF ISOENZYMES PHOSPHODIESTERASE TYPE 4 (PDE4 D), WHICH REGULATE THE ACTIVATION AND DEGRANULATION OF EOSINOPHILS, MAY BE USEFUL, RESPIRATORY, TREATMENT, AND RESPIRATORY DISORDERS BODY WEIGHT |