| abstract |
REFERS TO COMPOUNDS OF FORMULA (IA) or (IB), THEIR SALTS OR SOLVATES; WHERE: R1 IS C1-C3 ALKYL SUBSTITUTED WITH C3-C6 CYCLOALKYL, CONR5R6, HETERO-CYCLE LINKED THROUGH AN N, LIKE PIRAZOLYL, IMIDAZOLYL, AMONG OTHERS; R2 IS C1-C6-ALKYL; R3 IS C1-C6 ALKYL OPTIONALLY REPLACED WITH C1-C4 ALCOXY; R4 IS SO2NR7R8; R5 AND R6 IS H AND C1-C4 ALKYL OPTIONALLY REPLACED WITH C1-C4 ALCOXY OR TOGETHER WITH N FORM PIRROLIDINYL, PIPERIDINYL, AMONG OTHERS; R7 AND R8 NEXT TO N FORMAN 4-R10-PIPERAZINYL; R10 IS C1-C4 ALKYL OPTIONALLY REPLACED WITH OH, C1-C4 ALCOXY, or CONH2. A PREFERRED COMPOUND IS 5- {5- [4- (2-HYDROXYETHYL) PIPERAZIN-1-ILSULFONIL] -2-n-PROPOXIFENIL} -3-n-PROPIL-1- (PIRIDIN-2-IL) METHYL-1, 6-DIHYDRO-7H-PIRAZOLO [4,3-d] PIRIMIDIN-7-ONA, AMONG OTHERS. IT ALSO REFERS TO PROCEDURES FOR PREPARATION. COMPOUNDS OF FORMULA (IA) or (IB) ARE INHIBITORS OF THE GUANOSIN 3`, 5'-MONOPHOSPHATE CYCLE (cGMP PDE5) ENZYME, WHICH MAY BE USEFUL FOR THE CURE OR PROPHYLACTIC DYSFUNCTION DYSFUNCTION. FEMALE, PREMATURE LABOR, DYSMENORRHEA |