abstract |
IT REFERS TO A COMPOUND OF FORMULA (I) WHERE "A" IS A LINK, CH2, CHOH, C = NOR4, CO, NR5, O, S (O) n, n IS 0-2; R4 is H or ALKYL; R5 is H, ALKYL or ACYL; "Z" IS A GROUP OF FORMULA (B), WHICH IS PHENYL SUBSTITUTED BY R6 AND R7, (C), WHICH IS PIRIDINE SUBSTITUTED BY R8, (D) or (E), n1 IS 0-3; "X" IS O or S; R6 AND R7 ARE H, ALKYL, HALOGENOLALKYL, CYCLOALKYL, NR9R10, R9 AND R10 ARE H, ALKYL, ACIL or R6 AND R7 FORMETHYLLETHIOXYL or ETHYLENDIOXYL; R8 IS H, ALKYL, ALCOXYL, CYAN, AMONG OTHERS; R1 IS H, ALKYL, ALKYNYL, ALKYNYL, AMONG OTHERS; R2 IS H, ALKYL, ALCOXYL, AMONG OTHERS; R3 IS SO2R12 or SO2NR13R14, R12 IS ALKYL, HYDROXIALKYL, AMONG OTHERS; R13 IS H, ALKYL or ACIL; R14 IS H, I RENT, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE WHICH INCLUDES REACTIONING A FORMULA COMPOUND (a) WITH A FORCING AGENT OF FORMULA ZC (O) L, L IS AN OUTGOING GROUP UNDER ACILANT CONDITIONS, EITHER CHANGE ANY OF THEM. R6, R7, R8, R12. THE PREFERRED COMPOUNDS ARE 5- (4-FLUOROBENZOIL) -6-METOXI-2-NAFTALENSULFONAMIDA, 5- (4-METHYLBENZOIL) -6-METOXI-2 NAFTALENSULFONAMIDA, AMONG OTHERS. THE COMPOUND OF FORMULA (I) MAY BE USEFUL IN THE TREATMENT OF ANTI-INFLAMMATORY OR AUTOIMMUNE DISEASE, BECAUSE IT IS AN INHIBITOR OF PROSTAGLANDINE SYNTHESA I AND II (COX I AND COX II) |