http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-28099-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 1997-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a0d5b369b09e037d74fd0290716bbf8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ae22b32683e0bdd8c33774de3605644 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e91b5479eb97870b54a5451b28a57c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80a9ab84a5ffac803a1402afaed532f0 |
| publicationDate | 1999-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PE-28099-A1 |
| titleOfInvention | PROCESS FOR MAKING DERIVATIVES OF 2-AMINO-2-IMIDAZOLINE, GUANIDINE AND 2-AMINO-3,4,5,6-TETRAHYDROPYRIMIDINE |
| abstract | IT REFERS TO THE PROCEDURE FOR PREPARING THE COMPOUNDS (I), WHICH INCLUDES: (I) PREPARING RSC (= NR1) -NR2-CO-R3 IN A TWO-STEPS PROCEDURE, IN THE SAME CONTAINER, WHICH CONSISTS OF (a) RENT R1-NH-CS-NH-R2 USING AN ALKYLATING AGENT SUCH AS: CH3I, CH3Br, CH3Cl, (CH3) 2SO4, C2H5I, C2H5Br, C2H5Cl, (C2H5) 2SO4 AND C6H5-CH2Br; (b) ACILATE WHAT IS OBTAINED IN (a) WITH AN ANCILLATING AGENT SUCH AS: DITERT-BUTYL DICARBONATE, DIETHYLPYROCARBONATE, DIMETHYLPYROCARBONATE, ClCOOCH3, ClCOOC2H5, CH3COCl, C2H5COCl, (2 CO3CO5) 20, (2 CO2CO5) , (C (CH3) 3CO) 2O AND BENZOYL CHLORIDE, IN THE PRESENCE OF A BASE SUCH AS: N (C2H5) 3, N (CH3) 3, 4-DIMETHYLAMINOPYRIDINE, PYRIDINE, K2CO3, Na2CO3, KHCO3 AND NaHCO3; (ii) COUPLING THE INTERMEDIATE COMPOUND OF (i) WITH R4-Z-NH2, IN THE PRESENCE OF AN ORGANIC ACID SUCH AS CH3COOH, C2H5COOH, CH2ClCOOH, AMONG OTHERS, AT A TEMPERATURE THAT GOES FROM AMBIENT TEMPERATURE TO 150�C; WHERE: R1 AND R2 ARE METHYL, ETHYL, or BOTH COME TOGETHER, FORMING A 5 or 6-MEMBER RING; "Z" IS A CARBOCYCLE or HETEROCYCLE; R4 IS H, ALCOXY, ALKYLTIO, AMONG OTHERS. THIS PROCEDURE IMPROVES THE PERFORMANCE, THE PURITY OF THE PRODUCT, AND PROVIDES A SYNTHETIC FLEXIBILITY FOR THE PREPARATION OF SUCH COMPOUNDS THAT ACT AS AGONISTS OF ALPHA-2-ADRENORECEPTOR, BEING USEFUL IN THE TREATMENT OF HYPERTENSION, MIGRAN, AND BETWEEN |
| priorityDate | 1996-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.