| abstract |
It refers to analogs of PYY that have alanine at position 4, lysine at position 7, QRY as the C-terminal end, and a half-life extension group. The analogs of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogs and to medical use of the analogs. These compounds are used in the treatment and/or prevention of a variety of diseases, such as the treatment and/or prevention of excessive food intake, excess body weight, obesity, metabolic diseases and other conditions or disorders related to excess body weight or obesity, for example diabetes and cardiovascular disease. |