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filingDate 2014-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a533fc49639fab21d83e5f995de7aeca
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publicationDate 2021-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PE-20212110-A1
titleOfInvention DRY POWDER FORMULATION COMPRISING AN ANTICHOLINERGIC, A CORTICOSTEROID AND A BETA-ADRENERGIC FOR ADMINISTRATION BY INHALATION
abstract Related to a process for the preparation of a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic to be delivered by a dry powder inhaler (DPI); wherein said process comprises the steps: i) preselecting the excipient particles and the additive particles of fraction a) with a particle size in which at least 90% of all the particles have a volume diameter of less than 12 microns, and the volume median diameter of said particles is 3 to 7 microns; ii) preparing the fine particle fraction a), by co-mixing the excipient particles and the additive particles in a high energy apparatus for a period of less than 20 minutes; and iii) mixing said fraction of fine particles a), said fraction of coarse particles b) and all the micronized active ingredients. It also refers to a formulation comprising: a) a fraction of fine particles, 90 to 99.5% by weight of micronized particles of a physiologically acceptable excipient and 0.5 to 10% by weight of magnesium stearate, b) a fraction of coarse particles: physiologically acceptable excipient, where the ratio between fine particles a) and coarse particles b) is 1:99 and 30:70% by weight; c) a combination of micronized particles of glycopyrronium bromide, beclomethasone dipropionate and formoterol fumarate dihydrate as active ingredients.
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