| abstract |
The present invention relates to a compound of formula I, or an acceptable salt thereof, wherein: n is 1 or 2; R1, R2 and R3 are independently C1-C4 alkyl optionally substituted with hydroxy, CH3-O-, among others, or R2 and R3 together form a 3-6 membered carbocycle or a 4-6 membered heterocyclyl containing a selected heteroatom from the group consisting of N and O, or R1, R2 and R3 together form a 5-8 membered bicyclic carbocycle or a 6-8 membered bicyclic heterocyclyl containing a heteroatom selected from N and O; R4 is 5-6 membered heteroaryl, 5-6 membered heterocyclyl, among others; R5 is H or C1-C2 alkyl, or R4 and R5 together form a 4-6 membered heterocyclyl containing 1 heteroatom selected from N and O. Specific compounds are compounds 1.2, 1.3, 1.5, among others. It also refers to a pharmaceutical composition. These compounds are potent inhibitors of the Vanin 1 enzyme, being useful in the treatment of Vanin-related diseases. |