| abstract |
The present invention relates to compounds of formula I or a salt thereof, where A, B, D, X, R1, R2 and R8 are as defined in the invention, said compounds have properties to antagonize the proprotein convertase subtilisin -kexin type 9 (PCSK9). The invention also relates to pharmaceutical compositions comprising the compounds of Formula I or their salts or their base forms, and methods for treating hypercholesterolemia; where the inhibition of PCSK9 activity is associated with a reduction in cholesterol levels. |