| abstract |
The present invention relates to a compound of formula (I); where, n is 0-3; R1 is -H, -F, -gem-difluoro, -gem-dimethyl, -C1-4 alkyl, -CHF2, -CHF2CH3 or -CH2CH2F; and R2 is selected from -H, -CH3, -F, -Cl, -CN, or -OCH3 or pharmaceutically acceptable salts. A selected compound is 5- [5] - [2-cycloalkyl] -6-pyridazin-3-yl] -1H-pyrimidine-2,4-dione; 5- [5 - [(1S, 2R) -2-isopropylcyclopropyl] -6-methyl-pyridazin-3-yl] -1H-pyrimidine-2,4-dione. Said compound inhibits the activity of CD73 (enzyme 5'-nucleotidase or ecto-5'nucleotidase) and they are useful in the treatment against cancer. |