http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20201413-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y308-01002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2018-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acde3a746695dc63956bb22f54d9d70b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e20c3241fb456cb600d876c4f783dd6 |
| publicationDate | 2020-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PE-20201413-A1 |
| titleOfInvention | METHOD FOR THE PREPARATION OF CHIRAL ALPHA HALOALKANOIC ACIDS |
| abstract | The present invention refers to a method of selective hydrolysis of the S enantiomer of an alpha haloalkanoic acid of formula I, where X is a halogen and R is an alkyl chain of 1 to 6 carbon atoms, where said alkyl chain can be straight or branched in gamma or delta carbon atoms, characterized in that it comprises: i) providing a racemate of the R enantiomer and the S enantiomer of said alpha haloalkanoic acid, ii) providing a polypeptide having dehalogenase activity comprising an amino acid sequence SEQ ID NO. 1 or SEQ ID NO. 4, iii) make the racemate react for 1-8 hours, where the pH is in the range of 9-10 and the temperature is in the range of 15-35 ° C for the polypeptide with dehalogenase activity that comprises a sequence of amino acids SEQ ID NO. 1 or the pH is in the range of 9-10 and the temperature is in the range of 55-65 ° C for the polypeptide with dehalogenase activity that comprises an amino acid sequence SEQ ID NO. 4, where an enantiomeric excess of the R enantiomer of between 90.0 and 99.9% is reached after 1-8 hours. Said method is more cost-effective, more time-effective, and safer to enable and / or facilitate the separation of the R and S enantiomers from the alpha haloalkanoic acids of formula I. |
| priorityDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974 |
Total number of triples: 17.