| abstract |
REFERRING TO COMPOUNDS SELECTED AS: 4- (4 - {[2- (4-CHLOROPHENYL) -4,4-DIMETHYL CYCLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -N - [(3- NITRO-4 - {[(1S) -1- (TETRAHYDRO-2H-PYRAN-4-IL) ETHYL] AMINO} PHENYL) SULFONIL] -2- (1H-PYRROLO [2,3-b] PYRIDIN-5-ILOXI )BENZAMIDE; 4- (4 - {[2- (4-CHLOROPHENYL) -4,4-DIMETHYL CYCLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -N - [(3-NITRO-4 - {[ (5s, 8s) -1-OXASPIRO [4.5] DEC-8-ILMETIL] AMINO} PHENYL) SULFONIL] -2- (1H-PYRROLO [2,3-b] PYRIDIN-5-ILOXI) BENZAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE ACTIVITY OF THE ANTI-APOPTOTIC PROTEINS Bcl-2 BEING USEFUL TO TREAT CANCER |