| abstract |
Refers to cyclic peptide tyrosine tyrosine (PYY) compounds of Formula I: wherein p is 0 or 1; m is 0,1,2,3,4 or 5; n is 1, 2, 3, or 4; q is 0 or 1; provided that q is 1 only when Z30 is absent; BRIDGE is -Ph-CH2-S-, -triazolyl-, -NHC (O) CH2S-, -SH2C (O) NH-, among others; Z4 is K, A, E, S, or R; Z7 is A or K; Z9 is G or K, Z11 is D or K, Z22 is A or K, Z23 is S or K, Z26 is A or H, Z30 is L, W, absent, or K. The compound of Formula I is derived from Z34 and Z35, which is modified by one or more processes comprising amidation, glycosylation, carbamylation, or a pharmaceutically acceptable salt thereof. Said compounds modulate the activity of the Y2 receptor of the neuropeptide Y2. It also refers to a composition, method to prevent, treat or ameliorate obesity, type 2 diabetes, metabolic syndrome, insulin resistance, dyslipidemia, among others. |