| abstract |
It refers to derivatives of imidazole, a compound of formula I or a salt thereof in which R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, among others; R3 can be halogen, -CN, C1-3 alkyl, C1-3 alkoxy, -NO2, among others; a represents 0, 1 or 2. Preferred compounds are 5- (1 H -imidazol-2-yl) -1,3-dimethylpyridin-2 (1 H) -one; 5- (4-Bromo-1-ethyl-1h-imidazol-2-yl) -1,3-dimethylpyridin-2 (1H) -one; 1,3-dimethyl-5- (1 - ((tetrahydro-2H-pyran-4-yl) methyl) -1H-imidazol-2-yl) pyridin-2 (1H) -one. Said compound modulates the binding to proteins that contain bromodomins such as, for example, acetylated lysine residues and are useful in the treatment of diseases such as rheumatoid arthritis and cancer. |