| abstract |
Refers to a compound of formula i where l is CO2H, -C (O) O ((C1-C6) alkyl, among others; R1 can be H, linear or branched (C1-C6) alkyl, among others X, Y, Z can be -C (R´) (R´´) -, -C (R´´) 2, among others; Z and L optionally form a fused lactone ring that has 4 to 7 ring member atoms ; m, n, p are integers between 0 and 2; R2 and R3 taken together with the boron atom and oxygen form a ring of 4, 5, 6 or 7 members; v can be -C (R´) (R´ ´) -, -NR´, among others; W can be -C (R´) (R´´´) -; D can be linear or branched alkylene (C1-C5), linear or branched alkenylene (C2-C8) Preferred compounds are 1-amino-3- (2-boronoethyl) cyclopentane-1-carboxylic acid, 1-amino-3- (2-boronoethyl) -2-methylcyclopentane-1-carboxylic acid, 1-amino-acid hydrochloride. 3- (boronoethyl) cyclopentane-1-carboxylic Said small molecule therapeutic compounds are potent inhibitors of Arginase 1 and Arginase 2 activity. It also refers to a farm composition. aceutica and a method of treatment that are useful in treating cancer. |