| abstract |
It refers to compounds of formula (I), where Y1 and Y2 are CH2 or O; X1 and X2 are S or O; R1 is OH or NH2; R2 is NH2 or H, R3 OH or NH2; R4 is NH2 or H; R5 and R6 are F, OH, among others; R8 and R9 are H, CH2OC (O) R7, among others; R7 is aryl, heteroaryl, among others. It also refers to a pharmaceutical composition. These compounds are agonists of STING (stimulator of interferon genes) capable of maintaining a response of T cells to tumor antigens and are useful for the treatment of inflammation, allergic and autoimmune diseases, infectious diseases, among others. |