| abstract |
It refers to cyano thienotriazolepyrazine compounds of formulas I and II, where RA1 is H, halogen, among others; RA2 is H, halogen, among others; X1 is N or CR5; R5 is H, halogen, among others; RB is H, halogen, among others; R1 is H, halogen, alkyl, among others; R2 is H, halogen, alkyl, among others; RC is halogen, alkenyl, among others; ring C is aryl or heteroaryl; RM is -CN, -N (RF) 2; RF is H, optionally substituted alkyl, among others; c is 0, 1, 2, 3, or 4. Also refers to pharmaceutical compositions. Said compounds are bromodomain binding molecules and / or proteins that contain bromodomain and are useful for the treatment of proliferative and cardiovascular diseases, among others. |