| abstract |
Refers to carbocyclic compounds of formula (I), wherein R1 is amino, hydroxyl, C1-8 alkyl and C1-8 alkoxy; R2 is C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, among others; R3 is hydrogen, C1-8 alkyl, C1-8 haloalkyl, among others; R4 is C1-8 alkyl, C1-8 alkoxy, C1-8 haloalkyl, among others; R5 is halogen, hydroxyl, cyano, C1-8 alkyl, among others; R6 is halogen, cyano, hydroxyl, C1-8 alkyl and C3-6 cycloalkyl; each of Ra and Rb are, independently, hydrogen, C1-8 alkyl; or together they can form an oxo; n is 1, 2, 3, or 4; m is 0, 1 or 2; and p is 0 or 1. Said compounds are modulators of the orphan receptor gamma t linked to retinoids (RORyt), being useful for the treatment of diseases, disorders, syndromes or conditions mediated by RORyt, such as pain, inflammation, COPD, asthma, arthritis rheumatoid, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer |