| abstract |
REFERS TO AN ANTIBODY-DRUG CONJUGATE OF FORMULA (II) WHERE X = Y IS CH2-CH2, CH = CH, CH2-C (= O) OR CH2-NH; A IS A 5 OR 6 MEMBER HETERO CYCLIC RING OPTIONALLY SUBSTITUTED WITH F, C1-C6 ALKYL, AMONG OTHERS; R1 AND R2 ARE EACH H OR C1-C6 ALKYL, OR FORM A HETEROCICLYL OR CYCLOALKYL GROUP OF 3 TO 6 MEMBERS; p IS 1 TO 8; Ab IS AN ANTI-HER2, ANTI-CD22, ANTI-CD33, ANTI-Napi2b OR ANTI-CLL-1 ANTIBODY. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION INCLUDING THE CONJUGATED ANTIBODY-DRUG COMPOUND THAT IS USEFUL FOR THE TREATMENT OF CANCER |