| abstract |
REFERS TO ETHINYL DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1 IS LOWER ALKYL; R2 IS PHENYL OR PYRIDINYL; n IS 0 TO 2; V AND U ARE EACH O U CH2; L IS A HETEROARYL GROUP OF FIVE OR SIX ELEMENTS SUCH AS PYRIDINE, PYRIMIDINE, PIRAZOLE, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (8S) -3 '- [2,6-DIFLUORO-4- (2-PHENYLETINYL) PHENYL] -1'-METHYL-SPIRO [6,7-DIHYDRO-5H-ISOQUINOLIN-8,6'- HEXAHYDROPYRIMIDIN] -2 ', 4'-DIONA; (6S) -3- [2,6-DIFLUORO-4- [2- (3-PYRIDYL) ETHINYL] PHENYL] -1-METHYL-SPIRO [HEXAHYDROPYRIMIDIN-6,1'-TETRALIN] -2,4-DIONA; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE POSITIVE ALLOSTERIC MODULATORS (MAP) OF THE METABOTROPIC RECEPTOR GLUTAMATE 4 (mGluR4), BEING USEFUL FOR THE TREATMENT OF PARKINSON DISEASE, ANXIETY, EMESIS, AUTISM |