| abstract |
The invention relates to compounds of formula I where B is CN, (C1-C6) alkyl, heteroaryl, phenyl, among others; R1 is phenyl, heteroaryl, among others; R2 is (C1-C6) alkyl, (C1-C6) haloalkyl, among others; R3 is H or (C1-C6) alkyl; R4 is H, F or CN; R5 is H or (C1-C6) alkyl; R6 is phenyl, (C3-C7) cycloalkyl, among others. Preferred compounds are: (2R, 4R, 5S) -4-fluoro-1- (4-fluorophenyl) sulfonyl-N - [[5-fluoro-2- [2- (trifluoromethyl) pyrimidin-5-yl] -4- pyridyl] methyl] -5-methyl-pyrrolidine-2-carboxamide, among others. The compounds can be useful in treating diseases and conditions mediated by TRP Al, such as pain or asthma. |