| abstract |
REFERS TO BICYCLE QUINAZOLINONE DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1, R2, R3, R4, R5, R6, R7, R9, R10, R12, R13, R14, A1, A2, A3, n AND m ARE AS DEFINED IN THE DESCRIPTION. PREFERRED COMPOUNDS ARE: (3R) -3 - [[2- [6- (4-ACETYLPIPERAZIN-1-IL) -4-OXOQUINAZOLIN-3-IL] ACETYL] AMINO] -3- (4-CHLOROPHENYL) -N- METHYLPROPANAMIDE; (3R) -3 - [[2- [6- (4-ACETYLPIPERAZIN-1-IL) -4-OXOQUINAZOLIN-3-IL] ACETHYL] AMINO] -3- (4-CHLOROPHENYL) -N, N-DIMETHYLPROPANAMIDE; (3R) -3 - [[2- [6- (4-ACETYLPIPERAZIN-1-IL) -4-OXOQUINAZOLIN-3-IL] ACETYL] AMINO] -3- (4-CHLOROPHENYL) -N-PHENYLPROPANAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCESS AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF AUTOTAXIN (ATX) INHIBITING THE PRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) BEING USEFUL IN THE TREATMENT OF EYE CONDITIONS |