| abstract |
It refers to 4-methylsulfone-substituted piperidine urea derivative compounds of formula (I), wherein Ar1 is a 5-6 membered heteroaryl, Ar2 is a 5-10 membered aryl or heteroaryl; R1 and R2 are each H, F, C1-C4 alkyl, among others; R3 is H, F, OH and C1-C4 alkyl. Said compounds are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with systolic dysfunction or left and / or right ventricular systolic reserve. Synthesis and characterization of compounds are described, as well as methods for treating DCM and other forms of heart disease. |