| abstract |
It refers to a BACE1 inhibitor compound of formula (I), where A and B are heteroaryls, R1 and R2 are C1-C6 alkyl or halogeno-C1-C6 alkyl or R1 and R2 form a C3-cycloalkyl with the C atom. Optionally substituted C6; R3 is H, C3-C6 cycloalkyl, among others; R4 is H or -C1-C6 alkyl; R5 is C1-C6 alkyl or halogen-C1-C6 alkyl; R6 is halogen; R7 is amino, cyano, among others. A compound selected is (1R, 3R) -3- [2-fluoro-5- [3- (5-methoxypyrazin-2-yl) isoxazol-5-yl] phenyl] -3,6,6-trimethyl-1 -methylimino-1-oxo-2H-1,4-thiazin-5-amine, 2,2,2-trifluoroacetic acid; among others. It also refers to a composition. This compound is useful in the treatment of Alzheimer's disease |