| abstract |
REFERS TO COMPOUNDS DERIVED FROM TRIAZOLOPYRIMIDINE OF FORMULA (I) WHERE ----- IS A SINGLE LINK OR A DOUBLE LINK; R1 AND R2 ARE H O HALOGEN; R3 IS HALOGEN, PHENYL, AMONG OTHERS; R4 IS H, HALOGEN, OR C1-C4 ALKYL; R5 IS OH OR C1-C4 ALKYL; n IS 0 O 1. PREFERRED COMPOUNDS ARE: 8- (1,3-DIMETHYL-1H-PYRAZOLE-5-IL) -N - ((5-FLUORO-2,3-DIHYDROBENZOFURAN-4-IL) METHYL) - [ 1,2,4] TRIAZOLO [4,3-c] PYRIMIDIN-5-AMINE; N - ((5-FLUORO-2,3-DIHYDROBENZOFURAN-4-IL) METHYL) -8- (2-METHYLPYRIDIN-3-IL) - [1,2,4] TRIAZOLO [4,3-c] PYRIMIDIN- 5-AMINE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE REPRESSIVE COMPLEX OF POLYNOMIUM 2 (PRC2), BEING USEFUL IN THE TREATMENT OF LYMPHOMAS, TUMORS AND CANCER |