| abstract |
It refers to a modified release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising approximately (5 to 70)% w / w of the total dose of acarbose, b) a second part, G2A, comprising approximately (30 to 95)% w / w of the total dose of acarbose, c) a third part, G2B, comprising approximately (10 to 90)% w / w of the total dose of orlistat, and d) a quarter, G3, comprising about 10% w / w to about 80% w / w of the total orlistat dose; and the total concentration of acarbose and orlistat, respectively, in the composition of 100% w / w. This composition is useful in the treatment of metabolic diseases such as obesity, overweight and type 2 diabetes. |