| abstract |
It refers to a compound derived from hydroxyalkyl substituted phenyltriazole of formula (I), wherein R1 is H or methyl and R2A and R2B are independently H, F, Cl, CN, methyl, among others. A selected compound is 5- (4-chlorophenyl) -2 - {[1- (3-chlorophenyl) -5- (hydroxymethyl) -1H-1,2,4-triazol-3-yl] methyl} -4- [ (2S) -3,3,3-trifluoro-2-hydroxypropyl] -2,4-dihydro-3H-1,2,4-triazol-3-one, among others. It also refers to a preparation process and a pharmaceutical composition that contains it. Said compound is an antagonist of vasopressin V1A and V2 receptors, being useful in the treatment and / or prevention of cardiovascular and kidney diseases. |