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filingDate 2011-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_391a9e8c14302dd516d03b5fcae1d635
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publicationDate 2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber PE-20170923-A1
titleOfInvention A CRYSTALLINE FORM OF (R) -7-CHLORO-N- (QUINUCLIDIN-3-IL) BENZO [B] THIOPHENE-2-CARBOXAMIDE MONOHYDRATED HYDROCHLORIDE
abstract Refers to the crystalline forms I and II of the hydrochloride compound of (R) -7-chloro-N- (quinuclidin-3-yl) benzo [b] thiophene-2-carboxaxmide monohydrate, where the crystalline form I is characterized by its X-ray powder diffraction pattern having peaks expressed as 2 (theta) 4.50; 9.04; 14.60; 15.14; 15.80; 16.60; 18.16; 18.44; 19.48; 21.74 and 25.46 ± 0.20 degrees; and crystalline form II is characterized by its X-ray powder diffraction pattern having peaks expressed as 2 (theta): 4.48; 9.00; 13.58; 15.62; 16.48; 19.02; 19.44; 22.46 and 25.00 ± 0.20 degrees. It also refers to a pharmaceutical composition and a production process. This compound is an agonist of the alpha-7 nicotinic receptor and is useful in the treatment of CNS disorders associated with cognitive deficiencies.
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