| abstract |
It refers to 4-oxo-3,4-dihydro-1,2,3-benzotriazines compounds of formula (I) where m and n are 0, 1 or 2; R1 is cyano, halo, hydroxy, among others; R4 is cyano, halo, fluoromethoxy, among others; R5 is H, trifluoromethyl, among others. A compound selected is 2- (5-methoxy-4-oxobenzo [d] [1,2,3] triazin-3 (4H) -yl) -N- (1-p-tolylethyl) acetamide; among others. It also refers to a composition and a combination. Said compounds are modulators of the orphan G protein coupled receptor (GPR 139), being useful in the treatment of schizophrenia, autism spectrum disorder, among others. |