| abstract |
Refers to compounds of formula (I) wherein W1 and W2 are O, S, or N-OR '; R 'is lower alkyl; Y is -N (R5) -, -O-, among others; R1 is H, lower alkyl, among others; n is 1, 2 or 3; R2 and R3 are H, alkyl, among others, or R2 and R3 together with C form a cycloalkyl or heterocyclyl; R4a and R4b are H, halogen, among others; R5 is H, cyano or lower alkyl or R5 and R8 together with the atoms to which they are attached form a fused heterocyclyl; R6, R7 and R8 are H, hydroxy, among others. A preferred compound is: 6 - [(6-aminopyrimidin-4-yl) amino] -8-chloro-1'-methyl-spiro [2H-imidazo [1,5-a] pyridine-3,4'-piperidin] -1,5-dione; among others. It also refers to a pharmaceutical composition. Said compounds inhibit mitogen-activated protein kinase (Mnk) interaction kinase, being useful in the treatment of diseases such as cancer. |