| abstract |
Refers to 1- (cyclopent-2-en-1-yl) -3- (2-hydroxy-3- (arylsulfonyl) phenyl) urea derivatives of formula I, where: R1 and R2 are H, C1- alkyl C3, C1-C3 haloalkyl, halogen; R3 is F, Cl, CN; and R4 is C1-C6 alkyl, - (CH2) n-N (R4a) (R4b), among other options. These compounds are used in the treatment or prevention of diseases and conditions mediated by the CXCR2 receptor such as autoimmune and inflammatory diseases, such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Among the preferred compounds we have: (R) -1- (4-chloro-2-hydroxy-3 - ((4-methyltetrahydro-2H-pyran-4-yl) sulfonyl) phenyl) -3- (2-chlorocyclopent-2 -en-1-yl) urea; (R) -1- (3-tert-Butylsulfonyl) -4-cyano-2-hydroxyphenyl) -3- (2-methylcyclopent-2-en-1-yl) urea; among others. |