| abstract |
The present invention relates to tricyclic compounds of formula (I) where A is heterocycle, among others; X and Y are H, C1-C6 alkyl, among others; Z is hydrogen, halogen, among others; R1 is hydrogen, halogen, among others; R2 is hydrogen, halogen, among others; R7 is hydrogen, C1-6 alkyl, among others. Preferred compounds are: 2- [3- (dimethyl-1,2-oxazol-4-yl) -5 - [(S) -oxan-4-yl (phenyl) methyl] -5H-pyrido [3,2-b ] indol-7-yl] propan-2-ol; 2- [3- (dimethyl-1H-1,2,3-triazol-5-yl) -5 - [(1S) -4,4,4-trifiuoro-1-phenylbutyl] -5H-pyrido [3,2 -b] indol-7-yl] propan-2-ol; among others. It also refers to a pharmaceutical composition and a method of treatment. These compounds are useful as anticancer |